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Sionna Therapeutics

5.29

-0.2300-4.17%

Post-market: 5.27-0.0200-0.38%19:58 EDT

Volume:1.94M

Turnover:10.51M

Market Cap:238.04M

PE:-2.44

High:5.72

Open:5.54

Low:5.27

Close:5.52

52wk High:54.97

52wk Low:4.01

Shares:45.00M

Float Shares:16.73M

Volume Ratio:0.84

T/O Rate:11.59%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.1683

EPS(LYR):-1.8835

ROE:-32.34%

ROA:-21.54%

PB:0.90

PE(LYR):-2.81

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Overview Company News Filings

Sionna Therapeutics upgraded to Sector Perform from Underperform at RBC Capital

Sionna Therapeutics, Inc. : RBC Raises to Sector Perform from Underperform; Cuts Target Price to $5 from $23

THOMSON REUTERS

Tenax, Sionna Shares Sink After Trial Failures

Wedbush Downgrades Sionna Therapeutics to Neutral From Outperform, Adjusts PT to $5 From $53

MT Newswires Live

Sionna Therapeutics Shares Down 91% After Co's Experimental Drug Misses Mid-Stage Trial Goal

THOMSON REUTERS

Sector Update: Healthcare Stocks Edge Higher Premarket Monday

MT Newswires Live

Exchange-Traded Funds Lower, Equity Futures Mixed Pre-Bell Monday Amid Rising Oil Prices

MT Newswires Live

Sionna Shares Tumble After Cystic-Fibrosis Treatment Unexpectedly Misses Endpoint

Sionna Scraps Genetic Disorder Drug Program After Trial Setback; Shares Tank

U.S. Stocks on the MOVE-Apple, Barrick Mining, AbCellera Biologics

Top Premarket Decliners

MT Newswires Live

Sionna Falls After Experimental Drug Misses Mid-Stage Trial Goal

Sionna Therapeutics Says SION-719 Phase 2a Trial Misses Sweat Chloride Endpoint in Cystic Fibrosis

Sionna Therapeutics Reports Topline Data from Two Development Programs in Cystic Fibrosis and Provides Corporate Update

THOMSON REUTERS

Sionna Therapeutics, - Evaluating Sion-719 Trial Confounders to Inform Sion-451 Program Next Steps

THOMSON REUTERS

Sionna Therapeutics, - Ends Q2 with $268.30 Mln in Cash; Plans Capital Preservation Actions

THOMSON REUTERS

Sionna Therapeutics, - Sion-719 Phase 2a Trial Does not Meet Key Endpoint; Program Discontinued as Add-on

THOMSON REUTERS

RBC Capital Remains a Sell on Sionna Therapeutics, Inc. (SION)

Sionna Therapeutics is Maintained at Buy by Guggenheim

Sionna Therapeutics, Inc. Reports Results for the Quarter Ended June 30 - Earnings Summary

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Therapeutics upgraded to Sector Perform from Underperform at RBC Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2658193799","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658193799?lang=en_us&edition=fundamental","pubTime":"2026-08-10 23:00","pubTimestamp":1786374025,"startTime":"0","endTime":"0","summary":"RBC Capital analyst Brian Abrahams upgraded Sionna Therapeutics (SION) to Sector Perform from Underperform. Published first on TheFly – the ultimat...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-upgraded-to-sector-perform-from-underperform-at-rbc-capital-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-upgraded-to-sector-perform-from-underperform-at-rbc-capital-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658375459","title":"Sionna Therapeutics, Inc. : RBC Raises to Sector Perform from Underperform; Cuts Target Price to $5 from $23","url":"https://stock-news.laohu8.com/highlight/detail?id=2658375459","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658375459?lang=en_us&edition=fundamental","pubTime":"2026-08-10 22:58","pubTimestamp":1786373933,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260810:nFWN4471JO:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658993737","title":"Tenax, Sionna Shares Sink After Trial Failures","url":"https://stock-news.laohu8.com/highlight/detail?id=2658993737","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658993737?lang=en_us&edition=fundamental","pubTime":"2026-08-10 22:52","pubTimestamp":1786373520,"startTime":"0","endTime":"0","summary":"Shares of Tenax Therapeutics and Sionna Therapeutics tumbled Monday after the biotechs revealed separate late-stage trial failures.Tenax stock fell nearly 90% after a Phase 3 trial of its experimental heart-failure pill failed to help patients walk farther than those on a placebo. The trial measured how far patients could walk in six minutes-a standard test for heart failure treatments. A second trial goal measuring patient-reported symptoms also came up short.Meanwhile, shares of Sionna dropped 92% after a trial of its experimental cystic fibrosis drug missed its main goal. The drug, added to a treatment developed by Vertex Pharmaceuticals, was meant to help patients' lungs clear mucus more effectively, measured by a drop in sweat chloride levels. The company said it wouldn't continue development of the drug as an add-on treatment.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","TENX","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658415932","title":"Wedbush Downgrades Sionna Therapeutics to Neutral From Outperform, Adjusts PT to $5 From $53","url":"https://stock-news.laohu8.com/highlight/detail?id=2658415932","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658415932?lang=en_us&edition=fundamental","pubTime":"2026-08-10 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21:18","pubTimestamp":1786367886,"startTime":"0","endTime":"0","summary":"Healthcare stocks were edging higher premarket Monday, with the State Street Health Care Select Sector SPDR ETF (XLV) slightly advancing and the iShares Biotechnology ETF (IBB) up 0.5%.Sionna Therapeu","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4505","BK4139","LU0128526141.USD","BK4581","XBI","HCSG","SION","AXSM","BK4588","LABU","BK4535","BK4007","PTH","BK4137","ABCL","BK4585","BK4121","XLV","IBB","LU2324357040.USD","LU0029874061.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658311549","title":"Exchange-Traded Funds Lower, Equity Futures Mixed Pre-Bell Monday Amid Rising Oil Prices","url":"https://stock-news.laohu8.com/highlight/detail?id=2658311549","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658311549?lang=en_us&edition=fundamental","pubTime":"2026-08-10 21:18","pubTimestamp":1786367884,"startTime":"0","endTime":"0","summary":"The broad market exchange-traded fund SPDR S&P 500 ETF Trust (SPY) was down 0.1% and the actively traded Invesco QQQ Trust (QQQ) retreated 0.1% in Monday's premarket activity amid higher crude prices ","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["XLV","FDN","UNG","XLK","RTH.AU","SPY.AU","EETH","NESR","HOOD","QQQ","FAZ","VHT","CECO","PMR","SPY","VIS","IGV","SOXX","RTH","IYH","XLE","IBB","MNDY","SION","IYE","IPK","FAS","BITO","IYJ","VDC","XLP","XLI","EBAY","GME","XLY","BETH","IYK","VHT.AU","SLV","EQR","EXI","NESR.AU","IYW","GLD","VMRK","IVV","IGM","XSD","XLF","USO","XRT"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658313009","title":"Sionna Shares Tumble After Cystic-Fibrosis Treatment Unexpectedly Misses Endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2658313009","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658313009?lang=en_us&edition=fundamental","pubTime":"2026-08-10 21:07","pubTimestamp":1786367220,"startTime":"0","endTime":"0","summary":"Shares of Sionna Therapeutics tumbled after the company said a midstage, proof-of-concept trial of its treatment for cystic fibrosis didn't meet its key activity endpoint.The stock lost nearly 90% of its value in premarket trading Monday, falling to $5.27. Shares ended Friday's regular session at $51.04, up 24% year to date.The biopharmaceutical company said before the bell that potential confounders were observed in the trial, such as higher-than-anticipated levels of variability in individual sweat chloride levels.\"We are disappointed in the unexpected results from the Phase 2a trial,\" Chief Executive Mike Cloonan said. \"We are further evaluating the data to decide on next steps for the SION-451 dual combination.\"","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658270935","title":"Sionna Scraps Genetic Disorder Drug Program After Trial Setback; Shares Tank","url":"https://stock-news.laohu8.com/highlight/detail?id=2658270935","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658270935?lang=en_us&edition=fundamental","pubTime":"2026-08-10 20:03","pubTimestamp":1786363413,"startTime":"0","endTime":"0","summary":"Sionna scraps genetic disorder drug program after trial setback; shares tankAug 10 (Reuters)-Sionna TherapeuticsSION.Osaid on Monday it would stop developing its experimental drug as an addition to 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Stocks on the MOVE-Apple, Barrick Mining, AbCellera Biologics","url":"https://stock-news.laohu8.com/highlight/detail?id=2658935519","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658935519?lang=en_us&edition=fundamental","pubTime":"2026-08-10 19:55","pubTimestamp":1786362928,"startTime":"0","endTime":"0","summary":"BUZZ-U.S. STOCKS ON THE MOVE-Apple, Barrick Mining, AbCellera BiologicsAug 10 -S&P 500 and Nasdaq futures inched higher on Monday as investors assessed developments in the Middle East that could influence the reopening of the Strait of Hormuz, kicking off the week laden with crucial inflation data and earnings..N** Barrick Mining CorpB.N:BUZZ - Falls on Q2 profit missnL4N4470KX** Apple IncAAPL.O:BUZZ - Falls, Jefferies downgrades on anniversary iPhone concernsnL6N4470IQ** National Energy Services Reunited CorpNESR.O:BUZZ - Jumps on Q2 revenue beatnL6N4470ID** Varex Imaging CorpVREX.O:BUZZ - Jumps as Teledyne to buy X-ray imaging maker in $1.1 billion dealnL4N4470MN** Tenax Therapeutics IncTENX.O:BUZZ - Falls after heart drug misses late-stage study goalnL4N4470NC** AbCellera Biologics IncABCL.O:BUZZ - Gains as experimental drug reduces hot flashes in mid-stage trialnL4N4470NT** Sionna Therapeutics IncSION.O:BUZZ - Falls after experimental drug misses mid-stage trial 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