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Sionna Therapeutics

5.29

-0.2300-4.17%

Post-market: 5.27-0.0200-0.38%19:58 EDT

Volume:1.94M

Turnover:10.51M

Market Cap:238.04M

PE:-2.44

High:5.72

Open:5.54

Low:5.27

Close:5.52

52wk High:54.97

52wk Low:4.01

Shares:45.00M

Float Shares:16.73M

Volume Ratio:0.84

T/O Rate:11.59%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.1683

EPS(LYR):-1.8835

ROE:-32.34%

ROA:-21.54%

PB:0.90

PE(LYR):-2.81

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News

Vertex Has Multiple Portfolio Catalysts With Favorable Risk-Reward, RBC Says

MT Newswires Live

Why Sionna Therapeutics (SION) Is Down 90.9% After Ending SION-719 Add-On To Trikafta Therapy

Simply Wall St.

Sionna Therapeutics price target lowered to $5 from $38 at Freedom Broker

Sionna Therapeutics Cut to Neutral from Buy by BTIG

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Has Multiple Portfolio Catalysts With Favorable Risk-Reward, RBC Says","url":"https://stock-news.laohu8.com/highlight/detail?id=2658290503","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658290503?lang=en_us&edition=fundamental","pubTime":"2026-08-12 23:02","pubTimestamp":1786546971,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals  has multiple potential catalysts coming from its portfolio that provide a net positive risk-reward profile for the company, RBC Capital Markets said in a Wednesday note.The company is expected to present results from its phase 1 study of VX-828 in patients with cystic fibrosis in H2, with a positive readout potentially strengthening its competitive advantage in the space, RBC analysts said.Favorable data will likely result in modest upside, while unfavorable data will likely lead to little downside, the analysts added.Meanwhile, approval by the US Food and Drug Administration for Vertex's povetacicept in immunoglobulin A nephropathy, with a PDUFA date of Nov. 30, 2026, is likely due to strong interim phase 3 results, the analysts said.They said that the drug's differentiated profile could make it the preferred choice of most doctors.With Sionna Therapeutics  failing to demonstrate significant sweat chloride improvements as an add-on to Trikafta, one of the more 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Sionna Therapeutics (SION) Is Down 90.9% After Ending SION-719 Add-On To Trikafta Therapy","url":"https://stock-news.laohu8.com/highlight/detail?id=2658946453","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658946453?lang=en_us&edition=fundamental","pubTime":"2026-08-12 04:34","pubTimestamp":1786480479,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics recently reported that its Phase 2a PreciSION CF trial of NBD1 stabilizer SION-719 added to Trikafta did not improve sweat chloride levels, leading the company to discontinue SION-719 as an add-on therapy and to reassess its clinical plans.\nAt the same time, early data from SION-451 combination studies and a cash balance of about US$268.3 million give Sionna room to reconsider how it pursues cystic fibrosis therapies while preserving capital.\nWe’ll now examine how...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-sion/sionna-therapeutics/news/why-sionna-therapeutics-sion-is-down-909-after-ending-sion-7","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-sion/sionna-therapeutics/news/why-sionna-therapeutics-sion-is-down-909-after-ending-sion-7","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","SION","AIPO"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658792916","title":"Sionna Therapeutics price target lowered to $5 from $38 at Freedom Broker","url":"https://stock-news.laohu8.com/highlight/detail?id=2658792916","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658792916?lang=en_us&edition=fundamental","pubTime":"2026-08-11 22:15","pubTimestamp":1786457710,"startTime":"0","endTime":"0","summary":"Freedom Broker analyst Ilya Zubkov lowered the firm’s price target on Sionna Therapeutics (SION) to $5 from $38 and keeps a Hold rating on the shar...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-price-target-lowered-to-5-from-38-at-freedom-broker-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/sionna-therapeutics-price-target-lowered-to-5-from-38-at-freedom-broker-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2658991383","title":"Sionna Therapeutics Cut to Neutral from Buy by BTIG","url":"https://stock-news.laohu8.com/highlight/detail?id=2658991383","media":"Dow Jones","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2658991383?lang=en_us&edition=fundamental","pubTime":"2026-08-11 18:16","pubTimestamp":1786443360,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: 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