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SPYRE THERAPEUTICS INC

106.49

-1.3000-1.21%

Volume:1.01M

Turnover:108.82M

Market Cap:9.39B

PE:-52.98

High:110.00

Open:108.85

Low:105.71

Close:107.79

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:1.19

T/O Rate:1.25%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:9.83

PE(LYR):-53.91

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Overview Company News Filings

Spyre Therapeutics CMO Sheldon Sloan disposes of common shares worth $3.69 million

Spyre CEO Cameron Turtle sells $1.05 million common shares

Spyre Therapeutics grants stock options for 20,800 shares under inducement plan

Spyre Therapeutics Announces Grants of Inducement Awards

Analysts Conflicted on These Healthcare Names: Teladoc (TDOC), Spyre Therapeutics (SYRE) and Regeneron (REGN)

How Investors May Respond To Spyre Therapeutics (SYRE) Upsized Equity Raise After Positive SPY001 Phase 2 Data

Simply Wall St.

Wall Street Analysts Are Bullish on Top Healthcare Picks

Analysts Offer Insights on Healthcare Companies: Spyre Therapeutics (SYRE) and Revolution Medicines (RVMD)

Analysts Are Bullish on These Healthcare Stocks: Praxis Precision Medicines (PRAX), Spyre Therapeutics (SYRE)

Spyre Therapeutics closes follow-on offering, raises USD 463.5 million

BUZZ-U.S. STOCKS ON THE MOVE-Nike, PNC Financia, OSI Systems

BUZZ-Spyre Therapeutics gains after boosted $403 mln stock sale

Spyre Therapeutics Prices Upsized $403 Million Share Offering

MT Newswires Live

BRIEF-Spyre Therapeutics Announces Pricing Of Upsized $403 Million Public Offering Of Common Stock

Spyre Therapeutics Inc - Prices Public Offering of 6.5 Mln Shares at $62.00 per Share

THOMSON REUTERS

Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock

THOMSON REUTERS

Assessing Spyre Therapeutics (SYRE) Valuation After Recent Share Price Momentum And Premium P/B Multiple

Simply Wall St.

Stock Track | Spyre Therapeutics Soars 6.99% in Pre-Market on Multiple Analyst Target Price Hikes

Spyre Therapeutics Inc : Wedbush Raises Target Price to $80 From $65

THOMSON REUTERS

Spyre Therapeutics, Inc. : Wells Fargo Raises Target Price to $90 From $50

THOMSON REUTERS

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Therapeutics CMO Sheldon Sloan disposes of common shares worth $3.69 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2632262914","media":"Reuters","labels":["shareholding","insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632262914?lang=en_us&edition=fundamental","pubTime":"2026-05-02 09:35","pubTimestamp":1777685720,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics Chief Medical Officer Sheldon Sloan exercised options for 78,333 shares at USD 27.46 on May 1, 2026.Sloan sold 78,333 shares on May 1, 2026 in multiple trades at weighted average prices ranging from USD 69.53 to USD 75.37.Stock options beneficially owned totaled 321,667 following transactions.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on May 01, 2026, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260502:nNDLbpCsmW:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Spyre Therapeutics CMO Sheldon Sloan disposes of common shares worth $3.69 million","news_tag":"shareholding,insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632291556","title":"Spyre CEO Cameron Turtle sells $1.05 million common shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2632291556","media":"Reuters","labels":["shareholding","insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632291556?lang=en_us&edition=fundamental","pubTime":"2026-05-02 09:34","pubTimestamp":1777685697,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics CEO and director Turtle Cameron sold 15,000 common shares on May 1, 2026.Sales were executed under a Rule 10b5-1 trading plan adopted June 20, 2025.Transaction prices ranged from $69.54 to $74.96 per share.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on May 01, 2026, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260502:nNDL21tLKJ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632647122","title":"Spyre Therapeutics grants stock options for 20,800 shares under inducement plan","url":"https://stock-news.laohu8.com/highlight/detail?id=2632647122","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632647122?lang=en_us&edition=fundamental","pubTime":"2026-05-02 04:28","pubTimestamp":1777667306,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics granted stock options covering 20,800 common shares to four non-executive employees under its 2018 Equity Inducement Plan.Options carry a 10-year term with an exercise price of $69.42, set at May 1 close.Vesting starts with 25% on first anniversary of each employee’s start date, followed by monthly vesting of remaining balance.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260501:nNDL3YSRgM:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4112","IE00B3QW5Z07.USD","IE00BN0W2W23.USD","LU2210149790.SGD","LU2210150020.SGD","LU2095319765.USD","IE00BGHQF748.EUR","SG9999014021.USD","BK4588","SYRE","NDAQ","BK4585","IE00BKPKM429.USD","IE00B64PRP62.GBP","LU0314104364.USD","SG9999014039.USD","BK4139","SG9999014013.SGD","IE00BN0W2T93.GBP","IE00BN0W2V16.EUR","SG9999014005.SGD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632264710","title":"Spyre Therapeutics Announces Grants of Inducement Awards","url":"https://stock-news.laohu8.com/highlight/detail?id=2632264710","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632264710?lang=en_us&edition=fundamental","pubTime":"2026-05-02 04:28","pubTimestamp":1777667280,"startTime":"0","endTime":"0","summary":"WALTHAM, Mass., May  01, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company pioneering long-acting antibodies and antib","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2026/05/01/3286222/0/en/Spyre-Therapeutics-Announces-Grants-of-Inducement-Awards.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","LENZ","BK4139","BK4007","BK4539"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2631656750","title":"Analysts Conflicted on These Healthcare Names: Teladoc (TDOC), Spyre Therapeutics (SYRE) and Regeneron (REGN)","url":"https://stock-news.laohu8.com/highlight/detail?id=2631656750","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2631656750?lang=en_us&edition=fundamental","pubTime":"2026-04-30 22:41","pubTimestamp":1777560068,"startTime":"0","endTime":"0","summary":"Analysts have been eager to weigh in on the Healthcare sector with new ratings on Teladoc (TDOC), Spyre Therapeutics (SYRE) and Regeneron (REGN). T...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-conflicted-on-these-healthcare-names-teladoc-tdoc-spyre-therapeutics-syre-and-regeneron-regn-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-conflicted-on-these-healthcare-names-teladoc-tdoc-spyre-therapeutics-syre-and-regeneron-regn-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4504","LU2362541513.USD","LU2106854487.HKD","REGN","XBI","LU2468319806.SGD","LABU","LU0058720904.USD","LU0889565916.HKD","LU0823434740.USD","LU1861559042.SGD","BK4588","BK4137","LU2237438978.USD","LU0029874061.USD","LU0053666078.USD","LU0289739699.SGD","LU2023250504.SGD","LU0109394709.USD","SYRE","XLV","LU0823416689.USD","BK4548","LU0320765992.SGD","LU0882574055.USD","LU1861558580.USD","LU0823434583.USD","LU0128526141.USD","LU2089984988.USD","LU2362541273.HKD","BK4139","BK4167","LU1974910355.USD","LU2362540622.SGD","BK4567","BK4581","BK4534","BK4585","HCSG","LU0114720955.EUR","LU1917777945.USD","TDOC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2630733118","title":"How Investors May Respond To Spyre Therapeutics (SYRE) Upsized Equity Raise After Positive SPY001 Phase 2 Data","url":"https://stock-news.laohu8.com/highlight/detail?id=2630733118","media":"Simply Wall St.","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2630733118?lang=en_us&edition=fundamental","pubTime":"2026-04-27 04:05","pubTimestamp":1777233942,"startTime":"0","endTime":"0","summary":"In mid-April 2026, Spyre Therapeutics completed a US$403.00 million follow-on common stock offering at US$62.00 per share, shortly after reporting positive 12-week Phase 2 SKYLINE data for its ulcerative colitis candidate SPY001, which met its primary endpoint and showed a safety profile consistent with the a4ß7 class.\nThe decision to expand the offering from a prior US$300.00 million filing and add Jefferies as co-lead underwriter underscores how the SPY001 data have become a central 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Street Analysts Are Bullish on Top Healthcare Picks","url":"https://stock-news.laohu8.com/highlight/detail?id=2629034958","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629034958?lang=en_us&edition=fundamental","pubTime":"2026-04-21 21:00","pubTimestamp":1776776458,"startTime":"0","endTime":"0","summary":"There’s a lot to be optimistic about in the Healthcare sector as 2 analysts just weighed in on AnaptysBio (ANAB) and Spyre Therapeutics (SYRE) with...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/wall-street-analysts-are-bullish-on-top-healthcare-picks-blurbs-news-110?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/wall-street-analysts-are-bullish-on-top-healthcare-picks-blurbs-news-110?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LABU","LU0029874061.USD","XBI","BK4585","ANAB","BLSG","BLSX","BK4581","BK4139","BK4137","LU0128526141.USD","SYRE","BK4588","BK4112"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2628132711","title":"Analysts 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Therapeutic...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-are-bullish-on-these-healthcare-stocks-praxis-precision-medicines-prax-spyre-therapeutics-syre-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-are-bullish-on-these-healthcare-stocks-praxis-precision-medicines-prax-spyre-therapeutics-syre-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0128526141.USD","BK4585","SYRE","IE00B2B36J28.USD","IE00BJT1NW94.SGD","LU0029874061.USD","BK4588","IE00B4R5TH58.HKD","IE00BJJMRZ35.SGD","BLSX","LABU","BK4581","IE0002141913.USD","XBI","PRAX","IE00BFTCPJ56.SGD","LU0889565916.HKD","LU0320765992.SGD","LU0109394709.USD","BLSG","IE0009355771.USD","BK4139","BK4137","BK4112"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2628249311","title":"Spyre Therapeutics closes follow-on offering, raises USD 463.5 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2628249311","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2628249311?lang=en_us&edition=fundamental","pubTime":"2026-04-17 04:16","pubTimestamp":1776370607,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics closed an underwritten follow-on offering of 7,475,000 common shares at USD 62 per share.Gross proceeds totaled about USD 463.5 million before underwriting discounts, commissions, and offering expenses.Underwriters exercised option in full to buy 975,000 additional shares.Jefferies, Goldman Sachs, Evercore ISI, and Guggenheim Securities served as joint book-running 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newsletter","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260415:nL6N40Y0QD:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NVDW","SPRY","GTLB","HOOD","UNP","NKE","SYRE","NVDY","KMX","NVDA","ALLO","LLY","WINA","TEM","RGTI","STNE","ABUS","ASBP","AVGO","ANV","BIRD","PNC","AVGW","GLOO","SNVD.UK","IONQ","NEM","OSIS","DTIL","FNB","NXL","RVMD","QUBT","TE","TNGX","PDSB","NOV","CSX","FHN","LLYX","BAC","AEO","NVDL","WULF","NVDD","NRXP","EGBN","BORR"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2627128748","title":"BUZZ-Spyre Therapeutics gains after boosted $403 mln stock sale","url":"https://stock-news.laohu8.com/highlight/detail?id=2627128748","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627128748?lang=en_us&edition=fundamental","pubTime":"2026-04-15 21:19","pubTimestamp":1776259197,"startTime":"0","endTime":"0","summary":"BUZZ-Spyre Therapeutics gains after boosted $403 mln stock sale** Spyre Therapeutics' SYRE.O shares up 2.3% to $65.50 before the bell following above-planned $403 mln equity raise** Waltham, Massachusetts-based biotech late Tues sold 6.5 mln shares at $62, a 3.1% discount to stock's last sale** SYRE shares jumped ~23% to $63.27 on Mon after co said its drug, SPY001, showed a significant reduction in disease activity when testing patients with ulcerative colitis in a mid-stage trial** Subsequently, co launched $300 mln stock offering late Mon** Jefferies, Goldman Sachs, Evercore and Guggenheim joint bookrunners for offering** Through Tues close, SYRE stock up 95% YTD. It closed at $12.71 a year ago** Of 16 analysts, 10 rate the stock \"strong buy\", 6 \"buy\"; median PT $80, per LSEG 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Therapeutics Prices Upsized $403 Million Share Offering","url":"https://stock-news.laohu8.com/highlight/detail?id=2627409564","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627409564?lang=en_us&edition=fundamental","pubTime":"2026-04-15 15:21","pubTimestamp":1776237698,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics  said late Tuesday it priced its upsized underwritten public offering of 6.5 million shares at $62 apiece for gross proceeds of about $403 million.The company has also granted underwriters a 30-day option to purchase up to an additional $60.5 million of shares at the offering piece.The offering is expected to close on or about 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Announces Pricing Of Upsized $403 Million Public Offering Of Common StockApril 14 (Reuters) - Spyre Therapeutics Inc SYRE.O:SPYRE THERAPEUTICS ANNOUNCES PRICING OF UPSIZED $40","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260415:nTUAC81R7Y:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2627471464","title":"Spyre Therapeutics Inc - Prices Public Offering of 6.5 Mln Shares at $62.00 per Share","url":"https://stock-news.laohu8.com/highlight/detail?id=2627471464","media":"THOMSON 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