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Spruce Biosciences, Inc.

51.58

-0.4050-0.78%

Pre-market: 52.991.41+2.73%08:01 EDT

Volume:62.31K

Turnover:3.18M

Market Cap:148.24M

PE:-1.34

High:53.00

Open:52.48

Low:49.03

Close:51.99

52wk High:240.00

52wk Low:7.26

Shares:2.87M

Float Shares:2.29M

Volume Ratio:1.21

T/O Rate:2.73%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-38.4300

EPS(LYR):-50.8298

ROE:-105.98%

ROA:-40.03%

PB:1.77

PE(LYR):-1.01

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Overview Company News Filings

Spruce Biosciences, Inc : B. Riley Initiates Coverage with Buy Rating; Target Price $160

THOMSON REUTERS

Spruce Biosciences joins Russell 3000 Index

Spruce Biosciences names Agnieszka Jurecka vice president, medical affairs

Spruce Biosciences Appoints Agnieszka Jurecka, M.d., Ph.d., Mph, as Vice President, Medical Affairs

THOMSON REUTERS

Spruce Biosciences Initiated at Buy by Guggenheim

Spruce Biosciences names Eric Jordan as VP, Marketing

Spruce Biosciences Appoints Eric Jordan as Vice President, Marketing and Tina Gullotta as Vice President, Finance and Corporate Controller

THOMSON REUTERS

Spruce Biosciences Initiated at Buy by Jones Trading

Spruce Biosciences Reports Long-Term Data for Enzyme Replacement Therapy to Treat Genetic Disease MPS IIIB

MT Newswires Live

Spruce Biosciences initiated with a Buy at JonesResearch

Spruce says long-term TA-ERT data presented at MPS Symposium

Spruce Biosciences reports six-year tralesinidase alfa data showing sustained biomarker reductions, stabilized cognition in MPS IIIB

Spruce Biosciences Announces Long-Term Tralesinidase Alfa Enzyme Replacement Therapy Data in Sanfilippo Syndrome Type B (Mps Iiib) Presented at the 18TH International Mps Symposium

THOMSON REUTERS

Spruce Biosciences Is Maintained at Buy by HC Wainwright & Co.

Spruce Biosciences, Inc : H.c. Wainwright Cuts Target Price to $150 From $200

THOMSON REUTERS

Spruce Biosciences Announces Data Presentation At The 18Th International MPS Symposium

Spruce Biosciences to present long-term tralesinidase alfa data in Sanfilippo syndrome Type B at International MPS Symposium

Spruce Biosciences Announces Data Presentation at the 18TH International Mps Symposium

THOMSON REUTERS

Spruce Biosciences to present at Jefferies Global Healthcare Conference

Analysts’ Top Healthcare Picks: Spruce Biosciences (SPRB), CG Oncology, Inc. (CGON)

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Index","url":"https://stock-news.laohu8.com/highlight/detail?id=2647371579","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2647371579?lang=en_us&edition=fundamental","pubTime":"2026-06-29 20:15","pubTimestamp":1782735324,"startTime":"0","endTime":"0","summary":"Spruce Biosciences (SPRB) announced that it has been added as a member of the Russell 3000 Index, effective with the opening of U.S. equity markets...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-joins-russell-3000-index-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-joins-russell-3000-index-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2645697024","title":"Spruce Biosciences names Agnieszka Jurecka vice president, medical affairs","url":"https://stock-news.laohu8.com/highlight/detail?id=2645697024","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2645697024?lang=en_us&edition=fundamental","pubTime":"2026-06-22 20:00","pubTimestamp":1782129640,"startTime":"0","endTime":"0","summary":"Spruce Biosciences named Agnieszka “AJ” Jurecka vice president, medical affairs, as it prepares for a potential U.S. FDA decision on tralesinidase alfa.She most recently served as chief medical officer at a seed-stage gene therapy company developing CNS-directed therapies for lysosomal gene defects.Jurecka previously led rare-disease programs at CoA Therapeutics and Ultragenyx, with earlier medical affairs roles at Shire, Synageva, Aegerion, and 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Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643475732?lang=en_us&edition=fundamental","pubTime":"2026-06-16 20:42","pubTimestamp":1781613720,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SPRB/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  June 16, 2026 08:42 ET (12:42 GMT)","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643520383","title":"Spruce Biosciences names Eric Jordan as VP, Marketing","url":"https://stock-news.laohu8.com/highlight/detail?id=2643520383","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643520383?lang=en_us&edition=fundamental","pubTime":"2026-06-15 20:01","pubTimestamp":1781524901,"startTime":"0","endTime":"0","summary":"Spruce Biosciences named Eric Jordan vice president, marketing, as it prepares for a potential U.S. FDA approval and launch of TA-ERT.Jordan previously led marketing and launch planning for encaleret at BridgeBio.He earlier ran U.S. commercialization of Oxervate at Dompé Pharmaceuticals, helping build it into a $1 billion brand.Tina Gullotta joined as vice president, finance, corporate controller, tasked with scaling finance and reporting as Spruce moves toward commercialization.Gullotta was vice president, finance at Frontier Medicines, following senior finance roles at Sunesis Pharmaceuticals and Atara Biotherapeutics.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spruce Biosciences Inc. published the original content used to genera","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260615:nNDL7QcwGm:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["ATRA","SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643208045","title":"Spruce Biosciences Appoints Eric Jordan as Vice President, Marketing and Tina Gullotta as Vice President, Finance and Corporate Controller","url":"https://stock-news.laohu8.com/highlight/detail?id=2643208045","media":"THOMSON 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Genetic Disease MPS IIIB","url":"https://stock-news.laohu8.com/highlight/detail?id=2642699432","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642699432?lang=en_us&edition=fundamental","pubTime":"2026-06-09 05:45","pubTimestamp":1780955100,"startTime":"0","endTime":"0","summary":"Spruce Biosciences  said late Monday its long-term data for tralesinidase alfa enzyme replacement therapy in patients with fatal genetic disease Sanfilippo Syndrome Type B or MPS IIIB, demonstrated a rapid and durable reduction of heparan sulfate non-reducing end, which is a surrogate endpoint.Data also showed relatively preserved cognitive and non-cognitive outcomes, including communication and motor skills, over a six-year period, according to a statement.These findings support the therapy's potential as the first disease-modifying treatment option, the company said.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642343354","title":"Spruce Biosciences initiated with a Buy at JonesResearch","url":"https://stock-news.laohu8.com/highlight/detail?id=2642343354","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642343354?lang=en_us&edition=fundamental","pubTime":"2026-06-09 04:26","pubTimestamp":1780950396,"startTime":"0","endTime":"0","summary":"JonesResearch analyst Catherine Novack initiated coverage of Spruce Biosciences (SPRB) with a Buy rating and $135 price target The firm says its va...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-initiated-with-a-buy-at-jonesresearch-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-initiated-with-a-buy-at-jonesresearch-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642431494","title":"Spruce says long-term TA-ERT data presented at MPS 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with...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spruce-says-long-term-ta-ert-data-presented-at-mps-symposium-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spruce-says-long-term-ta-ert-data-presented-at-mps-symposium-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642313774","title":"Spruce Biosciences reports six-year tralesinidase alfa data showing sustained biomarker reductions, stabilized cognition in MPS IIIB","url":"https://stock-news.laohu8.com/highlight/detail?id=2642313774","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642313774?lang=en_us&edition=fundamental","pubTime":"2026-06-09 04:05","pubTimestamp":1780949142,"startTime":"0","endTime":"0","summary":"Spruce Biosciences reports six-year tralesinidase alfa data showing sustained biomarker reductions, stabilized cognition in MPS IIIB. Spruce Biosciences reported long-term data for tralesinidase alfa enzyme replacement therapy in Sanfilippo syndrome type B, presented June 4-7, 2026.Results included data previously presented at the 22nd Annual WORLD Symposium, extending follow-up to as long as six years.Treatment was associated with sustained disease-biomarker improvement, with cognitive function and daily functioning preserved versus declines in untreated natural history patients.Imaging and organ assessments were consistent with stabilization of disease-related changes, supporting a potential disease-modifying profile.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financia","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nNDLC4gpf:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642431354","title":"Spruce Biosciences Announces Long-Term Tralesinidase Alfa Enzyme Replacement Therapy Data in Sanfilippo Syndrome Type B (Mps Iiib) Presented at the 18TH International Mps Symposium","url":"https://stock-news.laohu8.com/highlight/detail?id=2642431354","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642431354?lang=en_us&edition=fundamental","pubTime":"2026-06-09 04:05","pubTimestamp":1780949100,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nTUA3BHBKF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640956880","title":"Spruce Biosciences Is Maintained at Buy by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2640956880","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640956880?lang=en_us&edition=fundamental","pubTime":"2026-06-01 19:12","pubTimestamp":1780312320,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SPRB/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  June 01, 2026 07:12 ET (11:12 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640495810","title":"Spruce Biosciences, Inc : H.c. 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