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Ionis Pharmaceuticals

60.44

+0.69501.16%

Volume:208.11K

Turnover:12.54M

Market Cap:10.04B

PE:-17.37

High:60.62

Open:60.60

Low:59.70

Close:59.74

52wk High:86.74

52wk Low:41.71

Shares:166.18M

Float Shares:161.92M

Volume Ratio:0.75

T/O Rate:0.13%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:22.84

PE(LYR):-25.38

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Overview Company News Filings

Jefferies Remains a Buy on Ionis Pharmaceuticals (IONS)

Ionis posts presentation on olezarsen-triglyceride reductions in severe hypertriglyceridemia

Ionis posts ENDO 2026 presentation on olezarsen pancreatitis prevention in severe hypertriglyceridemia

Ionis posts CORE-TIMI severe hypertriglyceridemia olezarsen data presentation

Ionis shares 24-month extension data on olezarsen in severe hypertriglyceridemia study

Fonds de solidarité FTQ joins $20 million CELYSTRA Pharma financing round

Ionis Pharmaceuticals director Peter N. Reikes files initial beneficial ownership statement

Ionis Pharmaceuticals Adds Veteran Leader to Board

Ionis adds former Alexion CEO Ludwig Hantson to board

BRIEF-Ionis Announces Appointment Of Ludwig Hantson, Ph.D. To Board Of Directors

Ionis Announces Appointment of Ludwig Hantson, Ph.d. to Board of Directors

THOMSON REUTERS

Ionis Pharmaceuticals (IONS) Receives a Buy from Guggenheim

Ionis posts presentation for 2026 annual shareholders meeting

Ionis director Spencer R. Berthelsen disposes of 8,000 common shares for $605,360

Ionis Pharmaceuticals Price Target Maintained With a $125.00/Share by HC Wainwright & Co.

Ionis Pharmaceuticals: Advancing Pipeline, HBV Phase III Success, and Robust Catalyst Flow Underpin Buy Rating

Ionis partner GSK reports B-Well 1, B-Well 2 trials meet primary endpoint

Ionis Partner GSK Announces Bepirovirsen Achieves Unprecedented Functional Cure Rates With Potential to Redefine Treatment for Chronic Hepatitis B

THOMSON REUTERS

A New, Powerful Cholesterol-Lowering Drug Is on the Horizon -- WSJ

U.S. RESEARCH ROUNDUP-CAVA Group, Eagle Materials, Vertiv

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Remains a Buy on Ionis Pharmaceuticals (IONS)","url":"https://stock-news.laohu8.com/highlight/detail?id=2643747201","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643747201?lang=en_us&edition=fundamental","pubTime":"2026-06-15 22:18","pubTimestamp":1781533131,"startTime":"0","endTime":"0","summary":"Jefferies analyst Akash Tewari maintained a Buy rating on Ionis Pharmaceuticals today and set a price target of $113.00. According to TipRanks, Tew...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/jefferies-remains-a-buy-on-ionis-pharmaceuticals-ions-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/jefferies-remains-a-buy-on-ionis-pharmaceuticals-ions-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643724780","title":"Ionis posts presentation on olezarsen-triglyceride reductions in severe hypertriglyceridemia","url":"https://stock-news.laohu8.com/highlight/detail?id=2643724780","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643724780?lang=en_us&edition=fundamental","pubTime":"2026-06-15 03:18","pubTimestamp":1781464717,"startTime":"0","endTime":"0","summary":"Analysis assessed whether baseline fibrate use changed olezarsen’s placebo-adjusted triglyceride effect at 6 months and 12 months.Triglyceride reductions appeared larger with background fibrates, with interaction p-values of 0.02 at 6 months and 0.004 at 12 months.Baseline cohort: 674 fibrate users vs 387 non-users; median triglycerides 863 mg/dL vs 706 mg/dL at randomization.Slides conclude results support further study of concomitant fibrate use with APOC3 inhibition.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief on June 14, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260614:nNDL2Zr7xz:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643247800","title":"Ionis posts ENDO 2026 presentation on olezarsen pancreatitis prevention in severe hypertriglyceridemia","url":"https://stock-news.laohu8.com/highlight/detail?id=2643247800","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643247800?lang=en_us&edition=fundamental","pubTime":"2026-06-15 03:18","pubTimestamp":1781464715,"startTime":"0","endTime":"0","summary":"Pooled Phase 3 CORE-TIMI 72a and CORE2-TIMI 72b data showed an 85% reduction in acute pancreatitis events vs placebo .Absolute risk reduction in total events was 5.2%, implying an NNT of 20 over 1 year.Benefit was reported as consistent across baseline triglyceride levels and prior pancreatitis status, with the highest absolute gains in higher-risk patients.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief on June 14, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260614:nNDL9bfP3j:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643973642","title":"Ionis posts CORE-TIMI severe hypertriglyceridemia olezarsen data presentation","url":"https://stock-news.laohu8.com/highlight/detail?id=2643973642","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643973642?lang=en_us&edition=fundamental","pubTime":"2026-06-13 02:27","pubTimestamp":1781288825,"startTime":"0","endTime":"0","summary":"Pooled analysis showed acute pancreatitis risk reduction with RR 0.15 , absolute risk reduction 5.2%, NNT 20 over 1 year.High-risk subgroup  showed RR 0.17 , absolute risk reduction 32.5%, NNT 4.Safety summary flagged higher injection-site reactions, more ALT/AST ≥3x ULN at 80 mg (7%), platelet count <100K/uL at 80 mg (7%).Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief on June 12, 2026, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260612:nNDL2t8MbY:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643297846","title":"Ionis shares 24-month extension data on olezarsen in severe hypertriglyceridemia study","url":"https://stock-news.laohu8.com/highlight/detail?id=2643297846","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643297846?lang=en_us&edition=fundamental","pubTime":"2026-06-13 02:21","pubTimestamp":1781288471,"startTime":"0","endTime":"0","summary":"Ionis presented new open-label extension data on June 12, 2026 at the National Lipid Association Scientific Sessions in Chicago.Patients who previously received a lower dose showed smaller liver fat shifts when they moved to the 80 mg regimen in the extension study.The longer-term readout supported a favorable safety profile, supporting continued development and potential commercial positioning in sHTG.Retention remained high, with more than 90% of eligible participants rolling into and staying in the extension study.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated b","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260612:nNDL4D8G8q:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642498422","title":"Fonds de solidarité FTQ joins $20 million CELYSTRA Pharma financing round","url":"https://stock-news.laohu8.com/highlight/detail?id=2642498422","media":"Reuters","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642498422?lang=en_us&edition=fundamental","pubTime":"2026-06-09 21:26","pubTimestamp":1781011602,"startTime":"0","endTime":"0","summary":"Fonds de solidarité FTQ joined founders and other investors in a $20 million private financing to launch CELYSTRA Pharma.CELYSTRA, launched in May 2026, is a Quebec-based biopharma focused on acquiring internationally developed therapies for underserved Canadian patients.The company’s first product is olezarsen , recently cleared by Health Canada for familial chylomicronemia syndrome.CELYSTRA also secured Canadian rights to Ionis Pharmaceuticals’ donidalorsen, under Health Canada review for hereditary angioedema prevention.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. QFL - Solidarity Fund of Quebec Workers published the original content used to generate this news brief on June 09, 2026, and is solely responsible for the information ","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260609:nNDL4BMXF7:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642434909","title":"Ionis Pharmaceuticals director Peter N. Reikes files initial beneficial ownership statement","url":"https://stock-news.laohu8.com/highlight/detail?id=2642434909","media":"Reuters","labels":["executive","shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642434909?lang=en_us&edition=fundamental","pubTime":"2026-06-09 04:59","pubTimestamp":1780952382,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals director Peter N. Reikes filed an initial Form 3 statement dated June 4, 2026.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on June 08, 2026, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nNDL40RVST:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive,shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642139435","title":"Ionis Pharmaceuticals Adds Veteran Leader to Board","url":"https://stock-news.laohu8.com/highlight/detail?id=2642139435","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642139435?lang=en_us&edition=fundamental","pubTime":"2026-06-09 01:19","pubTimestamp":1780939199,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals ( ($IONS) ) just unveiled an update. Ionis Pharmaceuticals on June 4, 2026, appointed veteran biopharmaceutical executive Lud...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-adds-veteran-leader-to-board?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-adds-veteran-leader-to-board?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642803435","title":"Ionis adds former Alexion CEO Ludwig Hantson to board","url":"https://stock-news.laohu8.com/highlight/detail?id=2642803435","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642803435?lang=en_us&edition=fundamental","pubTime":"2026-06-09 00:50","pubTimestamp":1780937418,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals named former Alexion CEO Ludwig Hantson to its board, effective immediately.Hantson led Alexion from 2017 to 2021 through its sale to AstraZeneca.He previously ran Baxter Bioscience, led the Baxalta spin-off as CEO, held senior roles at Novartis, spent 13 years at Johnson & Johnson.Ionis also added Peter Reikes to the board.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on June 08, 2026, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nNDL7bKzYL:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IE0034235188.USD","LU1023059063.AUD","LU0795875086.SGD","LU0158827948.USD","LU0912757837.SGD","LU1119994496.HKD","JNJ","LU0889566641.SGD","IE000M9KFDE8.USD","LU0823416689.USD","AZN.UK","LU0128525689.USD","LU2236285917.USD","LU2592432038.USD","LU2293690082.USD","LU0887340254.USD","LU1162221912.USD","IE0002141913.USD","LU1989772840.SGD","IONS","LU2129689431.USD","IE00BVYPNV92.GBP","LU1051770623.HKD","BK4581","LU2237443978.SGD","03165","BK4550","LU0957799991.USD","LU1481599808.USD","LU1880407132.USD","LU1894683348.USD","LU1732800096.USD","LU0070217475.USD","LU2023250330.USD","IE00B19Z3B42.SGD","LU1551013425.SGD","LU0976567544.SGD","LU2114397693.USD","LU2237443549.SGD","LU1496350171.SGD","LU2357627491.SGD","LU2023251221.USD","IE00BZ1G4Q59.USD","LU0949170772.SGD","LU2456880835.USD","LU2896262040.SGD","IE00B7SZLL34.SGD","LU1829250122.USD","LU2433249047.HKD","IE0000B7K699.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2641648678","title":"BRIEF-Ionis Announces Appointment Of Ludwig Hantson, Ph.D. To Board Of Directors","url":"https://stock-news.laohu8.com/highlight/detail?id=2641648678","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2641648678?lang=en_us&edition=fundamental","pubTime":"2026-06-08 19:09","pubTimestamp":1780916962,"startTime":"0","endTime":"0","summary":"BRIEF-Ionis Announces Appointment Of Ludwig Hantson, Ph.D. To Board Of DirectorsJune 8 (Reuters) - Ionis Pharmaceuticals Inc IONS.O:IONIS ANNOUNCES APPOINTMENT OF LUDWIG HANTSON, PH.D. TO BOARD OF DIR","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nTUA9G63LF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2641869554","title":"Ionis Announces Appointment of Ludwig Hantson, Ph.d. to Board of Directors","url":"https://stock-news.laohu8.com/highlight/detail?id=2641869554","media":"THOMSON REUTERS","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2641869554?lang=en_us&edition=fundamental","pubTime":"2026-06-08 19:00","pubTimestamp":1780916401,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nTUA9G63LF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2641144535","title":"Ionis Pharmaceuticals (IONS) Receives a Buy from Guggenheim","url":"https://stock-news.laohu8.com/highlight/detail?id=2641144535","media":"TIPRANKS","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2641144535?lang=en_us&edition=fundamental","pubTime":"2026-06-06 01:05","pubTimestamp":1780679114,"startTime":"0","endTime":"0","summary":"In a report released today, from Guggenheim maintained a Buy rating on Ionis Pharmaceuticals, with a price target of $106.00. The word on The Stree...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/ionis-pharmaceuticals-ions-receives-a-buy-from-guggenheim-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/ionis-pharmaceuticals-ions-receives-a-buy-from-guggenheim-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2641160372","title":"Ionis posts presentation for 2026 annual shareholders meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2641160372","media":"Reuters","labels":["conferences"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2641160372?lang=en_us&edition=fundamental","pubTime":"2026-06-05 05:29","pubTimestamp":1780608587,"startTime":"0","endTime":"0","summary":"Ionis shareholder meeting deck outlined a push to accelerate revenue growth toward sustained positive cash flow, targeting cash flow breakeven in 2028.DAWNZERA U.S. net product sales reached $16 million in Q1 2026, up 128% from Q4 2025.TRYNGOLZA U.S. net product sales totaled $27 million in Q1 2026, up 350% from Q1 2025; EU launch underway.Zilganersen for Alexander disease received FDA priority review with a PDUFA date of Sept. 22, 2026; positioned as the first independent neurology launch expected in 2026.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief on June 04, 2026, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260604:nNDL3QjmmX:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"conferences","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640182914","title":"Ionis director Spencer R. Berthelsen disposes of 8,000 common shares for $605,360","url":"https://stock-news.laohu8.com/highlight/detail?id=2640182914","media":"Reuters","labels":["shareholding","insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640182914?lang=en_us&edition=fundamental","pubTime":"2026-06-04 05:35","pubTimestamp":1780522507,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals director Spencer R. Berthelsen exercised options to buy 8,000 shares at USD 24.42 on June 1.He sold 8,000 shares at USD 75.67 the same day.He reported 156,013 shares owned directly following the transactions.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on June 03, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260603:nNDLcqJ57:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Ionis director Spencer R. Berthelsen disposes of 8,000 common shares for $605,360","news_tag":"shareholding,insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640995931","title":"Ionis Pharmaceuticals Price Target Maintained With a $125.00/Share by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2640995931","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640995931?lang=en_us&edition=fundamental","pubTime":"2026-06-01 19:45","pubTimestamp":1780314300,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  June 01, 2026 07:45 ET (11:45 GMT)","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2639692011","title":"Ionis Pharmaceuticals: Advancing Pipeline, HBV Phase III Success, and Robust Catalyst Flow Underpin Buy Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2639692011","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2639692011?lang=en_us&edition=fundamental","pubTime":"2026-05-28 23:45","pubTimestamp":1779983121,"startTime":"0","endTime":"0","summary":"William Blair analyst Myles Minter has reiterated their bullish stance on IONS stock, giving a Buy rating today. 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In the past, scientists found drugs that lowered levels of the particle a moderate amount but failed to reduce heart attacks and strokes in research studies, leaving patients with no approved 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