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Ionis Pharmaceuticals

43.30

-0.8600-1.95%

Pre-market: 43.450.1500+0.35%09:15 EDT

Volume:3.35M

Turnover:145.42M

Market Cap:7.20B

PE:-12.44

High:44.19

Open:43.76

Low:42.79

Close:44.16

52wk High:86.74

52wk Low:42.63

Shares:166.18M

Float Shares:161.92M

Volume Ratio:1.36

T/O Rate:2.07%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:16.36

PE(LYR):-18.18

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Overview Company News Filings

Royalty Pharma Falls After Novartis' Cholesterol Drug Fails in Study

U.S. Stocks on the MOVE-Sigma Lithium, Shake Shack, Novartis

Movement Alert｜Ionis Pharmaceuticals Falls 7.76% in Regular Trading, Partner Novartis Lp(a) Drug Fails Phase 3 Trial

Ionis Pharmaceuticals price target lowered to $104 from $110 at Morgan Stanley

Ionis Pharmaceuticals, Inc. : TD Cowen Cuts Target Price to $84 from $94

THOMSON REUTERS

Canaccord Genuity Sticks to Its Buy Rating for Ionis Pharmaceuticals (IONS)

Ionis Pharmaceuticals Price Target Cut to $100.00/Share from $115.00 by HC Wainwright & Co.

Analysts Offer Insights on Healthcare Companies: Dyne Therapeutics (DYN), NewAmsterdam Pharma Company (NAMS) and Ionis Pharmaceuticals (IONS)

Movement Alert｜Ionis Pharmaceuticals Falls 12.19% in Pre-Market Trading, Partner Novartis Lp(a) Drug Pelacarsen Fails Phase 3 Cardiovascular Outcomes Trial

Ionis Pharmaceuticals price target lowered to $56 from $69 at Goldman Sachs

Ionis Pharma Shares Down 13.1% Premarket After Co's Heart Drug Fails Late-Stage Trial

THOMSON REUTERS

Ionis Pharma Tumbles After Heart Drug Fails Late-Stage Trial

Movement Alert｜Ionis Pharmaceuticals Falls 9.78% Overnight, Partner Novartis Pelacarsen Phase 3 Cardiovascular Outcomes Trial Fails to Meet Primary Endpoint

Citi sees limited immediate downside for Ionis after pelacarsen failure

Stocks to Watch: Ionis Pharmaceuticals, Novartis, Corvex

Ionis Pharmaceuticals Updates on Novartis Pelacarsen Trial Outcome

Novartis announces Phase 3 pelacarsen study did not meet primary endpoint

Ionis-Novartis Heart Drug Misses Main Goal of Late-Stage Trial

Novartis Says Pelacarsen Heart Disease Drug Missed Primary Endpoint

Ionis Pharmaceuticals: Buy Rating Backed by FDA Approval of Zanvastro and Strengthened Neurology Pipeline Upside

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Pharma Falls After Novartis' Cholesterol Drug Fails in Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2666737149","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2666737149?lang=en_us&edition=fundamental","pubTime":"2026-09-09 00:40","pubTimestamp":1788885632,"startTime":"0","endTime":"0","summary":"BUZZ-Royalty Pharma falls after Novartis' cholesterol drug fails in study** Shares of Royalty PharmaRPRX.Ofall 6% to $60.14 in afternoon trade** RPRX buys royalties of future drugs from academic labs and biotechs** Swiss drugmaker Novartis'NOVN.Scholesterol drug pelacarsenfailsin a closely watched study** RPRX says its $500 million funding agreement with NOVN's partner IonisIONS.Owas structured to limit risk with stable and predictable royalties in another drug Spinraza and potential gains from pelacarsen** RPRX expects to recoup its total investment and earn a modest positive return despite pelacarsen's failure**  \"We had previously estimated combined 2032 end-market sales of $1.6B  and royalties of $80MM . A missed opportunity, but the growth outlook is little changed\" - Royalty Pharma** RPRX reiterates \"its 2030 Portfolio Receipts target of $4.7 billion or more\"** Including session's move, stock up 54.7% 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The decline was driven by news that partner Novartis...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Novartis Lp(a) Drug Fails Phase 3, Ionis Tumbles","news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665235378","title":"Ionis Pharmaceuticals price target lowered to $104 from $110 at Morgan Stanley","url":"https://stock-news.laohu8.com/highlight/detail?id=2665235378","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665235378?lang=en_us&edition=fundamental","pubTime":"2026-09-08 20:36","pubTimestamp":1788870980,"startTime":"0","endTime":"0","summary":"Morgan Stanley analyst Michael Ulz lowered the firm’s price target on Ionis Pharmaceuticals (IONS) to $104 from $110 and keeps an Overweight rating...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-104-from-110-at-morgan-stanley-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-104-from-110-at-morgan-stanley-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665320244","title":"Ionis Pharmaceuticals, Inc. : TD Cowen Cuts Target Price to $84 from $94","url":"https://stock-news.laohu8.com/highlight/detail?id=2665320244","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665320244?lang=en_us&edition=fundamental","pubTime":"2026-09-08 20:18","pubTimestamp":1788869913,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nFWN4500I3:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665437327","title":"Canaccord Genuity Sticks to Its Buy Rating for Ionis Pharmaceuticals (IONS)","url":"https://stock-news.laohu8.com/highlight/detail?id=2665437327","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665437327?lang=en_us&edition=fundamental","pubTime":"2026-09-08 19:35","pubTimestamp":1788867323,"startTime":"0","endTime":"0","summary":"In a report released today, Gary Nachman from Canaccord Genuity maintained a Buy rating on Ionis Pharmaceuticals, with a price target of $85.00. Na...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-sticks-to-its-buy-rating-for-ionis-pharmaceuticals-ions-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-sticks-to-its-buy-rating-for-ionis-pharmaceuticals-ions-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665275393","title":"Ionis Pharmaceuticals Price Target Cut to $100.00/Share from $115.00 by HC Wainwright & 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The pelacar...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-56-from-69-at-goldman-sachs-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-56-from-69-at-goldman-sachs-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665732457","title":"Ionis Pharma Shares Down 13.1% Premarket After Co's Heart Drug Fails Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665732457","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665732457?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:32","pubTimestamp":1788863565,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4500QY:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665839324","title":"Ionis Pharma Tumbles After Heart Drug Fails Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665839324","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665839324?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:22","pubTimestamp":1788862967,"startTime":"0","endTime":"0","summary":"BUZZ-Ionis Pharma tumbles after heart drug fails late-stage trial** Ionis Pharmaceuticals'IONS.Oshares fall 12.7% to $50.70 premarket** NovartisNOVN.Sand Ionis said late Friday their experimental drug pelacarsendid not cutthe risk of major heart attacks and strokes in patients with a genetic risk factor in a late-stage trial** The drug successfully lowered a dangerous genetic cholesterol, Lp, but it did not improve overall heart health outcomes** The trial failure was negative for biopharma sector perception because lowering Lp \"did not reduce cardiovascular events in the overall population\", say analysts at Leerink Partners**Amgen'sAMGN.Oand Eli Lilly'sLLY.Ndrugs \"lower Lp more than pelacarsen\" and could now facegreater scrutiny- brokerage** Amgen shares slip 5% to $415.01 before the bell** As of last close, IONS down 26.6% YTD","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4500PU:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4588","IE0002141913.USD","BK4566","LU2112291526.USD","LU2468319806.SGD","IBB","IE00BJT1NW94.SGD","LU0109394709.USD","LU2242646821.SGD","BK4581","LU0889565916.HKD","LU1571399168.USD","LU0320765992.SGD","LU1061106388.HKD","IONS","LU2089984988.USD","TBXU","BK4585","BK4599","IBBQ","LU0868494617.USD","LU1023059063.AUD","LU0122379950.USD","IE00B4R5TH58.HKD","AMGN","IE00B2B36J28.USD","PBE","LU2242652126.USD","PJP","LU0289739699.SGD","BBH","LU1057294990.SGD","LU1983299246.USD","SG9999001440.SGD","BK4534","04332","BK4139","BIB","IE00BFTCPJ56.SGD","LU0058720904.USD","BK4533","IE00BJJMRZ35.SGD","IE0009355771.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1170767998","title":"Movement Alert｜Ionis Pharmaceuticals Falls 9.78% Overnight, Partner Novartis Pelacarsen Phase 3 Cardiovascular Outcomes Trial Fails to Meet Primary Endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=1170767998","media":"Market Focus","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1170767998?lang=en_us&edition=fundamental","pubTime":"2026-09-08 08:21","pubTimestamp":1788826911,"startTime":"0","endTime":"0","summary":"On September 8, Ionis Pharmaceuticals fell 9.78% overnight, trading at $52.41/share, with turnover of $57,300. The decline was triggered by partner Novartis announcing on September 4 that pelacarsen,...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Novartis Pelacarsen Phase 3 Failure Sinks Ionis","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665552317","title":"Citi sees limited immediate downside for Ionis after pelacarsen failure","url":"https://stock-news.laohu8.com/highlight/detail?id=2665552317","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665552317?lang=en_us&edition=fundamental","pubTime":"2026-09-07 23:15","pubTimestamp":1788794109,"startTime":"0","endTime":"0","summary":"After Ionis’ (IONS) partner Novartis (NVS) disclosed that the pelacarsen Phase 3 Lp(a)HORIZON study failed to meet its primary endpoint of cardiova...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/citi-sees-limited-immediate-downside-for-ionis-after-pelacarsen-failure-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/citi-sees-limited-immediate-downside-for-ionis-after-pelacarsen-failure-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","LU0211331839.USD","BK4585","IE00BJT1NW94.SGD","BK4588","MEDX","IE00B2B36J28.USD","IE00B4R5TH58.HKD","LU0070302665.USD","PPH","BK4532","IE00BFTCPJ56.SGD","IE0002141913.USD","IONS","IE0009355771.USD","NVS","BK4578","BK4139","IE00BJJMRZ35.SGD","LU0208291251.USD","LU0320765489.SGD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665352693","title":"Stocks to Watch: Ionis Pharmaceuticals, Novartis, Corvex","url":"https://stock-news.laohu8.com/highlight/detail?id=2665352693","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665352693?lang=en_us&edition=fundamental","pubTime":"2026-09-05 06:58","pubTimestamp":1788562680,"startTime":"0","endTime":"0","summary":"A heart disease drug made by Ionis Pharmaceuticals and Novartis didn't meet its primary endpoint in a Phase 3 trial. Ionis shares slid 9.5% to $52.60 in after-hours trading on Friday, while Novartis shares were off 4.4% at $153.04.Corvex said it had a loss of $26.3 million in the first half of the year. The stock fell 7.5% to $13.63 after the bell.","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IE0009355771.USD","LU0070302665.USD","IE00BFTCPJ56.SGD","LU0320765489.SGD","BK4588","IE0002141913.USD","IE00B2B36J28.USD","LU0211331839.USD","MEDX","MOVE","PPH","IE00B4R5TH58.HKD","BK4585","IONS","IE00BJT1NW94.SGD","BK4532","BK4578","BK4007","IE00BJJMRZ35.SGD","NVS","BK4139","BK4170","LU0208291251.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665354295","title":"Ionis Pharmaceuticals Updates on Novartis Pelacarsen Trial Outcome","url":"https://stock-news.laohu8.com/highlight/detail?id=2665354295","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665354295?lang=en_us&edition=fundamental","pubTime":"2026-09-05 05:47","pubTimestamp":1788558478,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals ( ($IONS) ) has shared an announcement. On September 4, 2026, Ionis Pharmaceuticals reported that its partner Novartis’ Phase...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-updates-on-novartis-pelacarsen-trial-outcome?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-updates-on-novartis-pelacarsen-trial-outcome?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665535175","title":"Novartis announces Phase 3 pelacarsen study did not meet primary endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2665535175","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665535175?lang=en_us&edition=fundamental","pubTime":"2026-09-05 04:55","pubTimestamp":1788555312,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) partner Novartis (NVS) announced that the pelacarsen Phase 3 Lp(a)HORIZON study, a pioneering cardiovascular outcomes ...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/novartis-announces-phase-3-pelacarsen-study-did-not-meet-primary-endpoint-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/novartis-announces-phase-3-pelacarsen-study-did-not-meet-primary-endpoint-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0320765489.SGD","IE00B2B36J28.USD","IE00BJJMRZ35.SGD","BK4578","IE00BFTCPJ56.SGD","BK4585","MEDX","IE0002141913.USD","LU0070302665.USD","BK4588","IE00B4R5TH58.HKD","IE0009355771.USD","NVS","BK4139","BK4007","LU0211331839.USD","IONS","IE00BJT1NW94.SGD","BK4532","PPH","LU0208291251.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665418351","title":"Ionis-Novartis Heart Drug Misses Main Goal of Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665418351","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665418351?lang=en_us&edition=fundamental","pubTime":"2026-09-05 04:51","pubTimestamp":1788555074,"startTime":"0","endTime":"0","summary":"Ionis-Novartis heart drug misses main goal of late-stage trialSept 4 (Reuters)-Ionis PharmaceuticalsIONS.Oand partner Novartis'NOVN.Sexperimental drug to lower high levels of a type of fat and protein","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260904:nL4N44W1D6:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665235141","title":"Novartis Says Pelacarsen Heart Disease Drug Missed Primary Endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2665235141","media":"Dow Jones","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665235141?lang=en_us&edition=fundamental","pubTime":"2026-09-05 04:50","pubTimestamp":1788555000,"startTime":"0","endTime":"0","summary":"Novartis said a heart disease drug did not meet its primary endpoint in a Phase 3 study.The company on Friday said that the drug, pelacarsen, did not reduce the risk of cardiovascular events--including deaths, heart attacks, and strokes--compared to a placebo.The drug did succeed in lowering lipoprotein levels, Novartis said.\"These are not the results we hoped for, but they provide important evidence that advances scientific understanding of the relationship between Lp lowering and cardiovascular outcomes and may help inform future approaches to cardiovascular risk management,\" Chief Medical Officer Shreeram Aradhye said.Pelacarsen was initially discovered and developed by Ionis Pharmaceuticals, before Novartis exercised an option to license development and commercialization rights for the drug in 2019.Shares of Novartis declined 4.4% to $153.00 in after-hours trading on Friday. Ionis shares were flat.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IE0009355771.USD","MEDX","LU0208291251.USD","IONS","LU0320765489.SGD","PPH","IE00B2B36J28.USD","LU0070302665.USD","IE00BJJMRZ35.SGD","IE0002141913.USD","BK4007","BK4139","NVS","BK4585","LU0211331839.USD","IE00BFTCPJ56.SGD","IE00B4R5TH58.HKD","BK4532","IE00BJT1NW94.SGD","BK4588","BK4578"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665351966","title":"Ionis Pharmaceuticals: Buy Rating Backed by FDA Approval of Zanvastro and Strengthened Neurology Pipeline Upside","url":"https://stock-news.laohu8.com/highlight/detail?id=2665351966","media":"TIPRANKS","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665351966?lang=en_us&edition=fundamental","pubTime":"2026-09-05 04:35","pubTimestamp":1788554117,"startTime":"0","endTime":"0","summary":"William Blair analyst Myles Minter has reiterated their bullish stance on IONS stock, giving a Buy rating today. Myles Minter has given his Buy rat...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/ratings/ionis-pharmaceuticals-buy-rating-backed-by-fda-approval-of-zanvastro-and-strengthened-neurology-pipeline-upside-ratings-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/ratings/ionis-pharmaceuticals-buy-rating-backed-by-fda-approval-of-zanvastro-and-strengthened-neurology-pipeline-upside-ratings-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LABU","IONS"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":10,"pageCount":3,"totalSize":200,"code":"91000000","status":"200"}]}}