US StockDetailed Quotes

Provided by Tiger Trade Technology Pte. Ltd.

Ionis Pharmaceuticals

59.74

+0.98001.67%

Post-market: 60.650.9130+1.53%19:58 EDT

Volume:2.72M

Turnover:163.43M

Market Cap:9.93B

PE:-17.17

High:60.92

Open:59.64

Low:59.06

Close:58.76

52wk High:86.74

52wk Low:41.71

Shares:166.18M

Float Shares:161.92M

Volume Ratio:1.15

T/O Rate:1.68%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:22.58

PE(LYR):-25.09

Loading ...

Overview Company News Filings

Beneficial Ownership Change

Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Beneficial Ownership Change

Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Beneficial Ownership Change

Form SCHEDULE 13G - Statement of Beneficial Ownership by Certain Investors

Quarterly Report

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

{"basename":"","ssrTDKData":{"titleTemplate":"%s - Tiger Brokers","title":"Tiger Brokers HK | Online Trading in stocks, bonds & ETFS","description":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","keywords":"tiger trading,tiger security,tiger broker hk,tigers co ltd,tiger trade hk,tiger brokers hk,stock broker,securities broker,online brokerage,hong kong broker,hk broker,online stock trading,online trading platform,stock trading platforms,trading application,stock trading,stock trading hong kong,buying stocks in hong kong,tiger brokers","social":{"ogDescription":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.0a0bd8dc.png","ogUrl":"https://www.gotigerhk.com/stock/IONS/filings?page=2"},"companyName":"Tiger Brokers"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"HKG","license":"TBHK","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals","latestPrice":59.74,"timestamp":1787342400000,"preClose":58.76,"halted":0,"volume":2723906,"hourTrading":{"tag":"盘后","latestPrice":60.653,"preClose":59.74,"latestTime":"19:58 EDT","volume":111370,"amount":6657464.6882,"timestamp":1787356733552,"change":0.913,"changeRate":0.015283,"amplitude":0.021021},"delay":0,"changeRate":0.01667801225323356,"floatShares":161921007,"shares":166184322,"eps":-3.48,"marketStatus":"Not Yet Opened","change":0.98,"latestTime":"08-21 16:00:00 EDT","open":59.64,"high":60.915,"low":59.0601,"amount":163432603.08063,"amplitude":0.031567,"askPrice":0,"askSize":0,"bidPrice":0,"bidSize":0,"shortable":3,"etf":0,"ttmEps":-3.48,"tradingStatus":0,"nextMarketStatus":{"tag":"Pre-Mkt","tradingStatus":1,"beginTime":1787558400000},"marketStatusCode":0,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":58.76,"preHourTrading":{"tag":"盘前","latestPrice":59.55,"preClose":58.76,"latestTime":"09:29 EDT","volume":1362,"amount":81244.585728,"timestamp":1787318999999,"change":0.79,"changeRate":0.013445,"amplitude":0.020592},"postHourTrading":{"tag":"盘后","latestPrice":60.653,"preClose":59.74,"latestTime":"19:58 EDT","volume":111370,"amount":6657464.6882,"timestamp":1787356733552,"change":0.913,"changeRate":0.015283,"amplitude":0.021021},"volumeRatio":1.1533212267462611,"impliedVol":0.5297,"impliedVolPercentile":0.924},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":161921007,"roa":"-12.42%","roe":"-105.50%","lyrEps":-2.38125,"volumeRatio":1.1533212267462611,"shares":166184322,"dividePrice":0,"high":60.915,"amplitude":0.031567,"preClose":58.76,"low":59.0601,"week52Low":41.705,"pbRate":"22.58","psRate":"11.36","week52High":86.74,"institutionHeld":0.98,"latestPrice":59.74,"eps":-3.48,"divideRate":0,"volume":2723906,"delay":0,"ttmEps":-3.48,"open":59.64,"prevYearClose":79.11,"prevWeekClose":57.24,"prevMonthClose":51.77,"prevQuarterClose":79.29,"fiveDayClose":57.24,"twentyDayClose":56.55,"sixtyDayClose":76.49},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"market":"US","date":"2026-07-29","symbol":"IONS","fiscalQuarterEnding":"2026/06","expectedEps":-1.09,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1785297600000,"reportTimeType":"pre","actualEps":-0.7},{"market":"US","date":"2026-04-29","symbol":"IONS","fiscalQuarterEnding":"2026/03","expectedEps":-0.89,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1777435200000,"reportTimeType":"pre","actualEps":-0.56},{"market":"US","date":"2026-02-25","symbol":"IONS","fiscalQuarterEnding":"2025/12","expectedEps":-1.31,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1771995600000,"reportTimeType":"pre","actualEps":-1.41},{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.2308,"buy":0.5385,"hold":0.2308,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.5385,"analysts":26,"updateTime":1787112000000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2026-08-21","current":-17.166667,"percent":0.568755,"low":-1664.931905,"twenty":-46.83029,"median":-17.93492,"eighty":-11.52511,"high":882.260453,"avg":-65.086095,"sd":366.247252,"marketCap":9764990760},"quantilePoints":[{"date":"2021-08-27","current":-10.175088,"twenty":-43.823694,"median":23.306229,"eighty":141.027241,"marketCap":5593683271},{"date":"2021-09-03","current":-10.146845,"twenty":-43.823694,"median":22.806307,"eighty":135.009304,"marketCap":5578157024},{"date":"2021-09-10","current":-9.266185,"twenty":-43.823694,"median":22.273726,"eighty":92.336284,"marketCap":5094020420},{"date":"2021-09-17","current":-9.553748,"twenty":-43.823694,"median":22.105712,"eighty":90.484478,"marketCap":5252105842},{"date":"2021-09-24","current":-9.294428,"twenty":-43.823694,"median":21.894477,"eighty":89.822908,"marketCap":5109546667},{"date":"2021-10-01","current":-8.61917,"twenty":-43.823694,"median":21.739571,"eighty":88.160122,"marketCap":4738328221},{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-19","current":-49.051939,"twenty":-36.458718,"median":-16.773398,"eighty":-9.930898,"marketCap":12574072128},{"date":"2025-12-26","current":-50.960181,"twenty":-37.51116,"median":-16.804783,"eighty":-9.964551,"marketCap":13063234795},{"date":"2026-01-02","current":-49.987104,"twenty":-38.080464,"median":-16.872737,"eighty":-9.994875,"marketCap":12813794230},{"date":"2026-01-09","current":-51.522544,"twenty":-40.33867,"median":-16.913584,"eighty":-10.055281,"marketCap":13207392005},{"date":"2026-01-16","current":-48.786554,"twenty":-41.579494,"median":-16.936559,"eighty":-10.101905,"marketCap":12506042883},{"date":"2026-01-23","current":-51.680511,"twenty":-42.352038,"median":-16.969214,"eighty":-10.147872,"marketCap":13247885603},{"date":"2026-01-30","current":-53.001116,"twenty":-43.304049,"median":-17.016336,"eighty":-10.177655,"marketCap":13586412084},{"date":"2026-02-06","current":-52.748369,"twenty":-43.896106,"median":-17.042828,"eighty":-10.276361,"marketCap":13521622327},{"date":"2026-02-13","current":-51.674193,"twenty":-45.89007,"median":-17.08842,"eighty":-10.365331,"marketCap":13246265859},{"date":"2026-02-20","current":-52.536693,"twenty":-46.437268,"median":-17.113581,"eighty":-10.415699,"marketCap":13467360905},{"date":"2026-02-27","current":-34.265449,"twenty":-46.808807,"median":-17.154283,"eighty":-10.419492,"marketCap":13055136075},{"date":"2026-03-06","current":-32.554417,"twenty":-46.808807,"median":-17.180856,"eighty":-10.419492,"marketCap":12415831546},{"date":"2026-03-13","current":-31.332977,"twenty":-46.808807,"median":-17.209871,"eighty":-10.419492,"marketCap":11949990075},{"date":"2026-03-20","current":-30.891179,"twenty":-46.808807,"median":-17.218631,"eighty":-10.419492,"marketCap":11781494224},{"date":"2026-03-27","current":-32.155933,"twenty":-46.808807,"median":-17.24834,"eighty":-10.419492,"marketCap":12263854896},{"date":"2026-04-02","current":-32.541423,"twenty":-46.808807,"median":-17.287579,"eighty":-10.419492,"marketCap":12410875786},{"date":"2026-04-10","current":-33.104499,"twenty":-46.808807,"median":-17.33251,"eighty":-10.419492,"marketCap":12625625400},{"date":"2026-04-17","current":-32.597731,"twenty":-46.808807,"median":-17.370954,"eighty":-10.419492,"marketCap":12432350747},{"date":"2026-04-24","current":-32.090963,"twenty":-46.808807,"median":-17.417852,"eighty":-10.419492,"marketCap":12239076094},{"date":"2026-05-01","current":-37.78562,"twenty":-46.808807,"median":-17.460406,"eighty":-10.419492,"marketCap":12355028686},{"date":"2026-05-08","current":-38.422456,"twenty":-46.808807,"median":-17.499692,"eighty":-10.425443,"marketCap":12563259507},{"date":"2026-05-15","current":-38.250612,"twenty":-46.808807,"median":-17.54086,"eighty":-10.441583,"marketCap":12507070238},{"date":"2026-05-22","current":-38.301154,"twenty":-46.808807,"median":-17.626193,"eighty":-10.45769,"marketCap":12523596493},{"date":"2026-05-29","current":-39.084564,"twenty":-46.821444,"median":-17.65446,"eighty":-10.515842,"marketCap":12779753455},{"date":"2026-06-05","current":-37.972628,"twenty":-46.808807,"median":-17.690774,"eighty":-10.584827,"marketCap":12416175832},{"date":"2026-06-12","current":-37.31052,"twenty":-46.808807,"median":-17.738974,"eighty":-10.668419,"marketCap":12199681883},{"date":"2026-06-18","current":-37.558179,"twenty":-46.808807,"median":-17.769888,"eighty":-10.69486,"marketCap":12280660536},{"date":"2026-06-26","current":-39.595044,"twenty":-46.821444,"median":-17.818766,"eighty":-10.726786,"marketCap":12946668637},{"date":"2026-07-02","current":-40.024656,"twenty":-46.821444,"median":-17.854581,"eighty":-10.726786,"marketCap":13087141809},{"date":"2026-07-10","current":-32.483705,"twenty":-46.821444,"median":-17.871767,"eighty":-10.726786,"marketCap":10621424474},{"date":"2026-07-17","current":-27.621511,"twenty":-46.821444,"median":-17.880886,"eighty":-10.979464,"marketCap":9031598685},{"date":"2026-07-24","current":-28.23813,"twenty":-46.821444,"median":-17.925673,"eighty":-11.109046,"marketCap":9233219003},{"date":"2026-07-31","current":-15.666504,"twenty":-46.83029,"median":-17.93492,"eighty":-11.257113,"marketCap":8854300676},{"date":"2026-08-07","current":-16.022293,"twenty":-46.83029,"median":-17.93492,"eighty":-11.326236,"marketCap":9055383705},{"date":"2026-08-14","current":-16.42807,"twenty":-46.83029,"median":-17.93492,"eighty":-11.457268,"marketCap":9284718070},{"date":"2026-08-21","current":-17.277849,"twenty":-46.83029,"median":-17.93492,"eighty":-11.52511,"marketCap":9764990760}],"updateTime":1787521573082},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:2,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"21270800","market":"us","labels":[],"media":"sec.gov","original_id":"AN189761226000462-IONS","pdf_url":"","pub_time":1778817600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]","symbol":"IONS","title":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000189761226000462/0001897612-26-000462-index.htm","us_notice_code":"Form SCHEDULE 13G/A","us_title_en":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000189761226000462/xslSCHEDULE_13G_X02/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"SCHEDULE 13G/A","id":"NTFILE3knamyLtV96v2aaZ","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2026-05-15 12:00","pubTimestamp":1778817600,"title_zh":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21262200","market":"us","labels":[],"media":"sec.gov","original_id":"AN142284926000098-IONS","pdf_url":"","pub_time":1778781335000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]","symbol":"IONS","title":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/0001422849-26-000098-index.html","us_notice_code":"Form SCHEDULE 13G/A","us_title_en":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000142284926000098/xslSCHEDULE_13G_X02/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"SCHEDULE 13G/A","id":"NTFILE8MrTUN4ofnBFk8Hi","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2026-05-15 01:55","pubTimestamp":1778781335,"title_zh":"Form SCHEDULE 13G/A - Statement of Beneficial Ownership by Certain Investors: [Amend","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21254398","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000157-IONS","pdf_url":"","pub_time":1778644800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000157/0001972481-26-000157-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000157/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEJCuSweo4D9zwRj93","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-05-13 12:00","pubTimestamp":1778644800,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21208472","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000144-IONS","pdf_url":"","pub_time":1777867200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000144/0001972481-26-000144-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000144/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE3RfLebh6tSUe6sPM","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-05-04 12:00","pubTimestamp":1777867200,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21197249","market":"us","labels":[],"media":"sec.gov","original_id":"AN210011926000716-IONS","pdf_url":"","pub_time":1777521600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form SCHEDULE 13G - Statement of Beneficial Ownership by Certain Investors","symbol":"IONS","title":"Form SCHEDULE 13G - Statement of Beneficial Ownership by Certain Investors","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000210011926000716/0002100119-26-000716-index.htm","us_notice_code":"Form SCHEDULE 13G","us_title_en":"Form SCHEDULE 13G - Statement of Beneficial Ownership by Certain Investors","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000210011926000716/xslSCHEDULE_13G_X02/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"SCHEDULE 13G","id":"NTFILE3pWXc6yxUSu1besE","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2026-04-30 12:00","pubTimestamp":1777521600,"title_zh":"Form SCHEDULE 13G - Statement of Beneficial Ownership by Certain Investors","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21189224","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401526000177-IONS","pdf_url":"","pub_time":1777435200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/0000874015-26-000177-index.htm","us_notice_code":"Form 10-Q","us_title_en":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS, INC. 10-Q 03-31-2026","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/form10q.htm","primary":true,"translateUrl":"","linkName":"form10q.htm","type":"10-Q","id":"NTFILE2C7G1PBE5cELheFX","market":"us","size":1064154},{"description":"EXHIBIT 31.1","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/ex31-1.htm","primary":false,"translateUrl":"","linkName":"ex31-1.htm","type":"EX-31.1","id":"NTFILE4Jk4jEr8NmXZS9Tr","market":"us","size":8512},{"description":"EXHIBIT 31.2","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/ex31-2.htm","primary":false,"translateUrl":"","linkName":"ex31-2.htm","type":"EX-31.2","id":"NTFILEFTxamrCsAwr9a449","market":"us","size":8439},{"description":"EXHIBIT 32.1","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/ex32-1.htm","primary":false,"translateUrl":"","linkName":"ex32-1.htm","type":"EX-32.1","id":"NTFILE8cne8Z4WseMDvdTh","market":"us","size":4870},{"description":"EXHIBIT 10.1","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/ex10-1.htm","primary":false,"translateUrl":"","linkName":"ex10-1.htm","type":"EX-10.1","id":"NTFILEHJGspWBm3EoTdi1F","market":"us","size":22414},{"description":"EXHIBIT 10.2","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000177/ex10-2.htm","primary":false,"translateUrl":"","linkName":"ex10-2.htm","type":"EX-10.2","id":"NTFILEEVJVsaQF4X73qUTp","market":"us","size":10226}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2026-04-29 12:00","pubTimestamp":1777435200,"title_zh":"Form 10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21179611","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036126017637-IONS","pdf_url":"","pub_time":1777435200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036126017637/0001140361-26-017637-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126017637/ef20071749_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20071749_ex99-1.htm","type":"EX-99.1","id":"NTFILEALsfb23GQKv7ubFa","market":"us","size":335954},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126017637/ef20071749_8k.htm","primary":false,"translateUrl":"","linkName":"ef20071749_8k.htm","type":"8-K","id":"NTFILE3zmrHPbTKiye8UTH","market":"us","size":28437},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126017637/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEDJkv6b5TDny7Kg33","market":"us","size":24775}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2026-04-29 12:00","pubTimestamp":1777435200,"title_zh":"Form 8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21169083","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000138-IONS","pdf_url":"","pub_time":1777348800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000138/0001972481-26-000138-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000138/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE5g3QSef4fRN5sjAL","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-04-28 12:00","pubTimestamp":1777348800,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21044786","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036126015801-IONS","pdf_url":"","pub_time":1776744000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036126015801/0001140361-26-015801-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 7.01: Regulation FD Disclosure;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126015801/ef20071051_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20071051_ex99-1.htm","type":"EX-99.1","id":"NTFILEEKD3iRLjz2zX9ucL","market":"us","size":29547},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126015801/ef20071051_8k.htm","primary":false,"translateUrl":"","linkName":"ef20071051_8k.htm","type":"8-K","id":"NTFILE79Tm8ExPTVL31bQ6","market":"us","size":40625},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126015801/image00001.jpg","primary":false,"translateUrl":"","linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILE8Z5dg77Ds5AKn259","market":"us","size":3534}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2026-04-21 12:00","pubTimestamp":1776744000,"title_zh":"Form 8-K - Current report","summary_en":"Item 7.01: Regulation FD Disclosure;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21016278","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401526000164-IONS","pdf_url":"","pub_time":1776312000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000164/0000874015-26-000164-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000164/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE8mNQ4DSzhuvHuMuX","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-04-16 12:00","pubTimestamp":1776312000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21016275","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401526000163-IONS","pdf_url":"","pub_time":1776312000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000163/0000874015-26-000163-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000163/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE4CMm5YyjAQMtNfpw","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-04-16 12:00","pubTimestamp":1776312000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"21016273","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401526000162-IONS","pdf_url":"","pub_time":1776312000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000162/0000874015-26-000162-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000162/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE3A2K7W32VmKAVSxq","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-04-16 12:00","pubTimestamp":1776312000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20938720","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000123-IONS","pdf_url":"","pub_time":1774929600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000123/0001972481-26-000123-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000123/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEBLQH3yMGmBm1p6RM","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-31 12:00","pubTimestamp":1774929600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20861303","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000114-IONS","pdf_url":"","pub_time":1773892800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000114/0001972481-26-000114-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000114/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILECTx2GSESdRDiQBTh","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-19 12:00","pubTimestamp":1773892800,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20840706","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000103-IONS","pdf_url":"","pub_time":1773633600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000103/0001972481-26-000103-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000103/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEGfrzYX3eAJC4hPdA","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-16 12:00","pubTimestamp":1773633600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20820682","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000093-IONS","pdf_url":"","pub_time":1773172822000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/0001972481-26-000093-index.html","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000093/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE3VpaNqACqxMcXDBC","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-11 04:00","pubTimestamp":1773172822,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20816169","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000092-IONS","pdf_url":"","pub_time":1773087376000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/0001972481-26-000092-index.html","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000092/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE4V4a7LPsVGMumbeV","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-10 04:16","pubTimestamp":1773087376,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20812678","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036126008340-IONS","pdf_url":"","pub_time":1773028800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036126008340/0001140361-26-008340-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 7.01: Regulation FD Disclosure;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126008340/ef20067398_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20067398_ex99-1.htm","type":"EX-99.1","id":"NTFILEEU6hgifA7EqsaG1S","market":"us","size":12036},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126008340/ef20067398_8k.htm","primary":false,"translateUrl":"","linkName":"ef20067398_8k.htm","type":"8-K","id":"NTFILEFj85fa4EnA6KK1Kq","market":"us","size":32527},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036126008340/image00001.jpg","primary":false,"translateUrl":"","linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILEFRKsFkKHT5xYvrui","market":"us","size":3506}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2026-03-09 12:00","pubTimestamp":1773028800,"title_zh":"Form 8-K - Current report","summary_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 7.01: Regulation FD Disclosure;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20793316","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000082-IONS","pdf_url":"","pub_time":1772514000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000082/0001972481-26-000082-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000082/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE4Rnxmsz7SSRmeot8","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-03 13:00","pubTimestamp":1772514000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20793229","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248126000080-IONS","pdf_url":"","pub_time":1772514000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000080/0001972481-26-000080-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248126000080/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE9q5BFwPDJCa7xhPH","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2026-03-03 13:00","pubTimestamp":1772514000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":22,"pageCount":2,"totalSize":424,"code":"91000000","status":"200"}]}}