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Denali Therapeutics Inc.

24.92

-0.0300-0.12%

Post-market: 24.920.00000.00%19:30 EDT

Volume:680.99K

Turnover:16.96M

Market Cap:3.98B

PE:-8.79

High:25.37

Open:25.25

Low:24.60

Close:24.95

52wk High:27.30

52wk Low:12.58

Shares:159.85M

Float Shares:151.07M

Volume Ratio:0.67

T/O Rate:0.45%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.8353

EPS(LYR):-2.9700

ROE:-54.93%

ROA:-29.15%

PB:4.77

PE(LYR):-8.39

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Overview Company News Filings

Biogen - Phase 2B Luma Study of Biib122 Does Not Meet Primary or Secondary Endpoints

THOMSON REUTERS

Biogen - Co and Denali to Discontinue Development of Biib122 in Idiopathic Parkinson’s Disease

THOMSON REUTERS

Denali Therapeutics trading halted, news pending

NASDAQ TRADE HALT HALT NEWS PENDING AT 05:55 PM

Stock Track | Denali Therapeutics Soars 7.98% Pre-market on Sector Optimism After Biogen's Alzheimer's Therapy Advancement

BUZZ-Biogen climbs on plans to advance development of experimental Alzheimer's therapy

Denali Therapeutics Seeing Encouraging Signals From Avlayah Launch, Oppenheimer Says

MT Newswires Live

Analysts Offer Insights on Healthcare Companies: ANI Pharmaceuticals (ANIP), Definitive Healthcare Corp (DH) and Denali Therapeutics (DNLI)

Denali Therapeutics Inc reports results for the quarter ended March 31 - Earnings Summary

Denali Therapeutics Q1 net loss narrows as expenses fall

BRIEF-Denali Therapeutics Q1 Operating Expenses USD 137.357 Million

Denali Therapeutics Q1 Net Income USD -128.447 Million

THOMSON REUTERS

Denali Therapeutics (DNLI) Is Down 6.4% After Takeda Exits DNL593 Partnership - What's Changed

Simply Wall St.

Denali Therapeutics announces annual shareholder meeting via webcast

Denali Therapeutics CMO Peter Scott Chin files initial beneficial ownership statement

US FDA's accelerated approval for drugs needs more transparency, says research firm

How AVLAYAH’s Accelerated Approval and Takeda Exit Will Impact Denali Therapeutics (DNLI) Investors

Simply Wall St.

BUZZ-U.S. STOCKS ON THE MOVE-Tesla, Norfolk Southern, Denali

Denali Therapeutics Regains Full Rights to Dementia Drug Following Takeda Partnership Termination

MT Newswires Live

Denali Therapeutics regains full rights to DNL593

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...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-ani-pharmaceuticals-anip-definitive-healthcare-corp-dh-and-denali-therapeutics-dnli-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-ani-pharmaceuticals-anip-definitive-healthcare-corp-dh-and-denali-therapeutics-dnli-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU1559883803.SGD","BK4581","BK4585","LU0566484027.USD","DH","ANIP","XLV","BK4007","BK4139","XBI","BK4588","BK4548","BK4535","DNLI","LABU","BK4167"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633720951","title":"Denali 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","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260507:nL8N41K38B:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4535","BK4139","DNLI","BK4548"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633202172","title":"Denali Therapeutics Q1 net loss narrows as expenses fall","url":"https://stock-news.laohu8.com/highlight/detail?id=2633202172","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633202172?lang=en_us&edition=fundamental","pubTime":"2026-05-08 04:49","pubTimestamp":1778186957,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Q1 net loss narrows as expenses fallOverviewBiotechnology firm's Q1 net loss narrowed yr/yr as operating expenses declinedCompany received FDA approval and launched AVLAYAH for Hun","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260507:nL1N41K1JK:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4535","DNLI","BK4548","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633768961","title":"BRIEF-Denali Therapeutics Q1 Operating Expenses USD 137.357 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St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633628539?lang=en_us&edition=fundamental","pubTime":"2026-05-05 06:14","pubTimestamp":1777932895,"startTime":"0","endTime":"0","summary":"In early May 2026, Denali Therapeutics announced that partner Takeda will terminate their collaboration on DNL593 for strategic reasons unrelated to efficacy or safety, returning full development and commercialization rights to Denali. \nThis shift gives Denali complete control over DNL593 and its underlying TransportVehicle technology, which it expects to further highlight with planned phase I/II data by the end of 2026.\nWe will now examine how Denali regaining full rights to DNL593 could...","market":"hk","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/denali-therapeutics-dnli-is-down-64-after-takeda-exits-dnl59","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/denali-therapeutics-dnli-is-down-64-after-takeda-exits-dnl59","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4535","AIPO","BK4139","DNLI","BK4548"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629806887","title":"Denali Therapeutics announces annual shareholder meeting via webcast","url":"https://stock-news.laohu8.com/highlight/detail?id=2629806887","media":"Reuters","labels":["conferences","event"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629806887?lang=en_us&edition=fundamental","pubTime":"2026-04-22 04:34","pubTimestamp":1776803649,"startTime":"0","endTime":"0","summary":"Denali Therapeutics set annual shareholder meeting for June 3, 2026 via virtual webcast.Shareholders will vote on election of three Class III directors to serve until 2029.Meeting agenda includes ratification of Ernst & Young as independent auditor for fiscal 2026.Investors will also cast advisory vote on executive compensation.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Denali Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on April 21, 2026, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260421:nNDL9BVpM1:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"conferences,event","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4535","DNLI","BK4548","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629177255","title":"Denali Therapeutics CMO Peter Scott Chin files initial beneficial ownership statement","url":"https://stock-news.laohu8.com/highlight/detail?id=2629177255","media":"Reuters","labels":["executive","shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629177255?lang=en_us&edition=fundamental","pubTime":"2026-04-21 07:22","pubTimestamp":1776727370,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Chief Medical Officer Peter Scott Chin filed an initial Form 3 disclosing 170,612 common shares held.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Denali Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on April 20, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260420:nNDL8KL9gh:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive,shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["DNLI","BK4535","BK4548","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2627302290","title":"US FDA's accelerated approval for drugs needs more transparency, says research firm","url":"https://stock-news.laohu8.com/highlight/detail?id=2627302290","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627302290?lang=en_us&edition=fundamental","pubTime":"2026-04-16 20:00","pubTimestamp":1776340800,"startTime":"0","endTime":"0","summary":"US FDA's accelerated approval for drugs needs more transparency, says research firmBy Sneha S K April 16 (Reuters) - The U.S. Food and Drug Administration should be more transparent when granting 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AVLAYAH’s Accelerated Approval and Takeda Exit Will Impact Denali Therapeutics (DNLI) Investors","url":"https://stock-news.laohu8.com/highlight/detail?id=2626925687","media":"Simply Wall St.","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2626925687?lang=en_us&edition=fundamental","pubTime":"2026-04-08 22:23","pubTimestamp":1775658220,"startTime":"0","endTime":"0","summary":"In late March 2026, Denali Therapeutics announced that the FDA granted accelerated approval for AVLAYAH, the first blood-brain-barrier-crossing biologic for treating neurologic manifestations of Hunter syndrome in eligible pediatric patients, while in early April 2026 it received notice that Takeda will end their DNL593 co-development agreement, returning all rights and future obligations to Denali.\nTogether, these developments highlight Denali’s transition toward independently advancing its...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/how-avlayahs-accelerated-approval-and-takeda-exit-will-impac","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/how-avlayahs-accelerated-approval-and-takeda-exit-will-impac","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","BK4211","BK4535","DNLI","ISBC","BK4548"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2625142603","title":"BUZZ-U.S. STOCKS ON THE MOVE-Tesla, Norfolk Southern, Denali","url":"https://stock-news.laohu8.com/highlight/detail?id=2625142603","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2625142603?lang=en_us&edition=fundamental","pubTime":"2026-04-07 01:51","pubTimestamp":1775497861,"startTime":"0","endTime":"0","summary":"BUZZ-U.S. STOCKS ON THE MOVE-Tesla, Norfolk Southern, DenaliWorkspace search string for individual stock moves: STXBZThe Day Ahead newsletter: https://refini.tv/3LI4BU7The Morning News Call 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Termination","url":"https://stock-news.laohu8.com/highlight/detail?id=2625673846","media":"MT Newswires Live","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2625673846?lang=en_us&edition=fundamental","pubTime":"2026-04-06 17:28","pubTimestamp":1775467681,"startTime":"0","endTime":"0","summary":"Denali Therapeutics  said Friday it regained full control of its investigational frontotemporal dementia therapy after Takeda Pharmaceuticals  terminated their joint development agreement.Takeda ended the commercialization partnership for strategic reasons rather than any concerns regarding the medication's safety or effectiveness, the company said.Denali Therapeutics will continue advancing the Phase 1/2 study, which recently completed enrollment with 40 participants and is expected to generate biomarker results by the end of this year, it said.Preliminary data from healthy volunteers demonstrated that the treatment successfully increased targeted protein levels in the brain without producing any significant safety signals, Denali said.Shares of Denali Therapeutics were up 1.6%, and shares of Takeda were down 2% in Monday premarket activity.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LENZ","BK4539","TAK","BK4139","DNLI","BK4535","BK4007","BK4548"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2625260176","title":"Denali Therapeutics regains full rights to DNL593","url":"https://stock-news.laohu8.com/highlight/detail?id=2625260176","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2625260176?lang=en_us&edition=fundamental","pubTime":"2026-04-06 09:15","pubTimestamp":1775438108,"startTime":"0","endTime":"0","summary":"Denali Therapeutics (DNLI) announced that it has received notification from Takeda (TAK) of its decision to terminate the collaboration agreement b...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-regains-full-rights-to-dnl593-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-regains-full-rights-to-dnl593-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LENZ","DNLI","TAK","BK4539","BK4548","BK4535","BK4139","BK4007"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":5,"pageCount":3,"totalSize":87,"code":"91000000","status":"200"}]}}