MannKind Says Phase 1b Study Shows Idiopathic Pulmonary Fibrosis Treatment Generally Safe, Well-Tolerated

MT Newswires Live
Jul 29

MannKind's (MNKD) phase 1b study evaluating nintedanib dry powder inhalation in patients with idiopathic pulmonary fibrosis showed that the drug was generally safe and well-tolerated, meeting its primary endpoint, the company said Wednesday.

The study, which enrolled 27 patients across 10 US sites and assessed two multiple-ascending dose regimens, showed that 60% reported no cough and 30% reported mild cough, according to a statement.

There were no serious adverse events, no drug-related gastrointestinal side effects, and no treatment discontinuations or dose reductions, MannKind said.

The company said it is enrolling patients for the phase 2 trial, which is expected to have around 210 participants across 85 sites worldwide and is designed to further evaluate the safety, tolerability, and efficacy of the drug.

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