Premarket Movers | KPTI Plunged 67% as the XPORT-EC-042 Trial Failed to Hit Primary Endpoint

Tiger Newspress

Jul 31

Karyopharm Therapeutics shares plunged over 67% in pre-market trading on Friday as the XPORT-EC-042 Trial Failed to Hit Primary Endpoint.

Karyopharm announced topline results from its Phase 3 XPORT-EC-042 trial evaluating selinexor as a maintenance-only therapy compared to placebo in adult patients with TP53 wild-type advanced or recurrent endometrial cancer. The trial did not meet its primary endpoint of progression free survival. A trend favoring the selinexor arm was observed in the modified intent to treat population, with a median PFS of 12.75 months in the selinexor arm compared to 7.43 months in the placebo arm. The safety and tolerability profile of selinexor was consistent with its established safety profile, with no new safety signals observed.

Karyopharm intends to complete a full evaluation of the data from the XPORT-EC-042 trial and plans to present the data at a future medical meeting. The results of the XPORT-EC-042 trial do not affect ongoing trials of selinexor in other potential indications.

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