InSilico Medicine Cayman TopCo (INSILICO, stock code 03696) will hold its Annual General Meeting electronically through the eVoting Portal on 2 June 2026 at 9:00 a.m. Hong Kong time. Shareholders may attend and vote online or appoint proxies by submitting forms to Tricor Investor Services no later than 48 hours before the meeting.

Key ordinary resolutions to be tabled include:

• Financial Statements: Consideration and adoption of the audited consolidated financial statements and the directors’ and auditor’s reports for the financial year ended 31 December 2025.

• Board Composition: Re-election of five directors—executives Dr. Aleksandrs Zavoronkovs and Dr. Feng Ren, and independent non-executives Dr. Denitsa Milanova, Dr. Jingsong Wang and Mr. Roman Kyrychynskyi—alongside authorization for the board to set directors’ remuneration.

• Auditor: Re-appointment of Deloitte Touche Tohmatsu as external auditor with board-delegated authority to determine remuneration.

• Share Mandates: – A repurchase mandate allowing the board to buy back up to 10% of issued shares (excluding treasury shares) as at the date of approval. – An issuance mandate permitting the board to allot and deal with additional shares up to 20% of issued shares (excluding treasury shares). – Conditional extension of the issuance mandate by the number of shares repurchased under the 10% buyback authority.

All resolutions will be decided by poll. Each fully paid share carries one vote. Completion of the proxy form does not preclude shareholders from voting through the eVoting Portal on the day of the meeting.